Structural requirements in 20-oxo-steroids for interaction with the binding site of 20.BETA.-hydroxysteroid dehydrogenase.
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چکیده
منابع مشابه
Structural features of ring C of 20-oxo steroids and the interaction with cortisone reductase.
Kinetic measurements were made with cortisone reductase (20-dihydrocortisone-NAD(+) oxidoreductase, EC 1.1.1.53) and a series of substrates which differed in shape, size and electronic character in the region adjacent to C-11, C-14 and C-18. Structural changes at C-11 in these substrates resulted in up to 660-fold changes in the apparent K(m) value, up to 200-fold changes in the apparent V(max....
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1981
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.29.476